Role of Human Leukocyte Antigens in Studying Population Diversity
نویسندگان
چکیده
Human Leukocyte Antigen (HLA) loci widely known for their role in generation of immune responsesare often considered to be effective in reconstructing human phylogenies due to high degree of polymorphism and rarity of recombination observed at HLA loci. In this review, we have made an attempt to discuss the role of HLA in immune response. Further we have tried to highlight the evolutionary significance of HLA diversity. The reason of high degree of HLA diversity is because of gene conversion and recombination. These evolutionary forces lead the HLA molecule to be most the most suitable marker to study the population diversity. © Kamla-Raj Enterprises 2007Anthropology Today: Trends, Scope and Applications Anthropologist Special Volume No. 3: 355-365 (2007)Veena Bhasin & M.K. Bhasin, Guest EditorsAuthors’ Address: Suraksha Agrawal, Sanjeev Srivastava and Piyush Tripathi, Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow (UP) 226 014, Uttar Pradesh, India Telephone: 091-522 -2668004-8 Ext 2338, 2346, 2347, Fax: 091-522 -2668973/2668017 E-mail: [email protected]
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